NEWEST is a 2-in-1 injectable which combines Polynucleotide (PN-HPT) with Hyaluronic Acid (HA) to support skin quality and improve skin elasticity and hydration. Developed by Mastelli in Italy, it is derived from purified trout DNA. The treatment works within the skin by supporting fibroblast activity and collagen production.
NEWEST is used to improve hydration and elasticity, as well as boost skin rejuvenation effects for smooth, radiant skin while correcting the appearance of ageing or damaged skin.
NEWEST Skin Booster is an injectable skin treatment that uses polynucleotides (PN-HPT) and Hyaluronic Acid (HA) to support skin repair and improve overall skin quality. It is derived from purified trout DNA and is commonly used to address concerns such as fine lines, uneven skin texture, enlarged pores, and dehydrated skin.
NEWEST is a patented formulation developed by Mastelli Srl in Italy. It combines three key ingredients — PN-HPT (polynucleotides), hyaluronic acid (HA), and mannitol (MN) — which work together to support skin hydration, skin quality, and overall skin condition.
The combination of polynucleotides and hyaluronic acid (HA) works within the skin to support skin repair and improve overall skin quality. Polynucleotides help support fibroblast activity, which plays a role in collagen production and skin regeneration. At the same time, hyaluronic acid helps maintain skin hydration and supports the skin’s natural moisture balance, contributing to improved skin texture and elasticity.
The formulation also includes mannitol, which helps stabilise hyaluronic acid and reduce its breakdown after injection. In addition, mannitol functions as a free radical scavenger, helping to reduce oxidative stress within the skin. Together, these ingredients support skin revitalisation and hydration while helping to improve the appearance of ageing or damaged skin over time.
NEWEST® is a patented formulation that combines three key ingredients — PN-HPT™, Hyaluronic Acid (HA), and Mannitol (MN) — that work synergistically to enhance skin quality and support a refreshed, confident appearance.
When combined with HA, PN-HPT™ becomes even more effective, increasing fibroblast stimulation by up to 20%. Mannitol (MN) further supports the formulation by helping to slow the degradation of HA, extending its benefits and reducing breakdown by up to 30%.
Hyaluronic acid helps support the skin’s moisture levels, improving overall skin hydration and suppleness.
Polynucleotides help support fibroblast activity, which plays a role in maintaining collagen and supporting skin renewal.
The formulation helps support smoother skin texture and improved skin elasticity.
Treatment may help improve the appearance of fine lines, uneven skin texture, and other visible signs of skin ageing.
The NEWEST procedure is non-surgical, so minimal downtime is expected. Some minor redness or bruising may be visible, but they will naturally subside within a day or two. In most cases, you can comfortably resume your daily activities immediately after the treatment.
DNA fragments derived from Italian trout using HPT technology are combined with Hyaluronic Acid (HA) to support skin revitalisation and collagen regeneration. This formulation helps improve the appearance of enlarged pores, acne scars, and fine lines.
After treatment with NEWEST®, skin may appear more radiant, with smoother-looking texture and improved elasticity. It can be used on both the face and body and may complement other aesthetic treatments as part of an overall skin rejuvenation plan.
Yes, NEWEST® is generally considered safe when administered by a qualified medical doctor.
Polynucleotides and Hyaluronic Acid used in these treatments have been widely studied in regenerative medicine and are designed to stimulate collagen production, improve hydration, and enhance skin healing while being compatible with human tissue.
As with most injectable aesthetic treatments, some patients may experience mild and temporary effects such as redness or small injection marks at the treatment site, which usually resolve within a short time. A consultation with our doctor is recommended to determine if the treatment is suitable for you.
The treatment can be safely combined with other energy-based treatments for optimal results by accelerating the production of collagen in the skin. Energy-based treatments that are compatible with Polynucleotide treatment:
Avoid exercising for 24 hours after treatment. Avoid extreme heat or direct sun exposure as well for at least 3 days. Avoid cosmetic products containing retinol for 3 days.