Nucleofill Singapore: 5 Points Skin-Lifting Injectable Treatment with Active Polynucleotides

Natural ageing is a gradual and continuous process that begins in early adulthood. It can start as earlier as mid twenties and when this happens, our bodies start to stop producing as much collagen each year which causes our skin to lose elasticity, together with its structure and natural glow. Ageing skin also appears to be much more thinner and paler, as well as saggy and loose.

Regain natural healthy skin with Nucleofill, which is an anti-ageing injection treatment which helps to reverse and slow age signs of ageing via minimal injection points, discomfort and pain.

Benefits of Nucleofill:

  • Skin Lifting & Skin Hydration
  • Antioxidant Effect
  • Anti-Inflammatory Properties
  • 5 Points Injection Procedure

Treatment price $1500 nett


$1500 nett


30 Minutes



No. of Sessions

3 sessions

What is Nucleofill?

Nucleofill is a new line of biostimulating gels that contains natural high-viscosity active polynucleotides (with a concentration 2.5%), specially designed for skin rejuvenation and protection.

Nucleofill deepy regenerates the skin to achieve these 3 main effects:

How does Nucleofill works?

Nucleofill works due its main ingredient – Polynucleotides (PN), to stimulate the skin to rebuild using a three-way mechanism: Skin Lifting, Antioxidation, Skin Hydration.

1. Skin Lifting Effect

Polynucleotides have an effect on fibroblast receptors in the skin, stimulating fibroblasts and the production of type 1 collagen and elastin to improve skin elasticity. This results in the thickening and lifting of the skin.

2. Anti-Oxidation Effect

Nucleofill play an immediate “scavenger” action against free radicals. As Polynucleotides in the extracellular environment destroy the free radicals, which in turn leads to the reduction of oxidative stress in the skin.

3. Skin Hydration Effect

Nucleofill has a strong hydrating ability, as polynucleotides binds water molecules like an “electrostatic sponge”, this leads to long-lasting deep hydration to skin tissues, ensuring cellular well-being.

Nucleofill Singapore Review

Treatment Time

30 mins

Recommended Interval

3 sessions monthly (maintenance every 6 months)

Effects of Nucleofill

Last for 9-12 months

Recovery Time



$1500 Nett

Detailed doctor consultation is required to curate a personalized treatment plan for your desired aesthetic goals.

Who is suitable for Nucleofill?

Nucleofill is ideal for people who experienced the loss of skin firmness and hydration. Individudals that have thin, atrophic, dehydrated or ageing skin in general can choose Nucleofill as an anti-ageing treatment.

Fine lines and wrinkles
Lacking of radiance
Dehydrated skin
Exposed to oxidative stress

What results can be achieved with Nucleofill?

The results that can be achieved with the triple actions of Nucleofill is an overall skin rejuvenation. Skin becomes lifted and tighter, moisturized and softer, with a healthy looking complexion and well-rested appearance.

What happens during Nucleofill treatment?

Nucleofill treatment requires 5 injection points on each sides of the face. The points are safe, the low probability of blood vessels and nerves in the treated areas.

Treatment is generally comfortable with no downtime. You may feel a slight pinching and stretching of the skin during the procedure which is bearable.

Numbing cream is optional but will be provided for patients who are sensitive to pain.

FAQ on Nucleofill Treatment in Singapore

Nucleofill is Europe CE approved and it contains highly purified Polynucleotides without any sugars or proteins or any other substances that maybe sensitizing or allergenic.

This minimizes the risk of allergies and complications for this bio-restructuring treatment, making it a safe treatment.

The common side effects for Nucleofill are mild swelling, bruising or redness at the injection site, which will subside within 1-2 days. For patients with thinners skin, the bumps may stay for a while longer.

Other than that, no other side effects have been reported.

Nucleofill treatment has minimal pain and downtime. The treatment requires 5 injection points on each side of the face (10 injection points for the entire face). The injection points are far from major nerves and blood vessels, which reduces the risks of pain, bruising or swelling.

During the treatment, a slight pinching and stretching of skin may be felt. Patients who are sensitive to pain, numbing cream is provided to minimise any pain and discomfort.

In order to obtain the best results, Nucleofill is performed over a course of 3 treatments every once a month.

For initial course, we usually recommend 3 treatments every one a month to kickstart biostimulation process, subsequently it can be repeated every 3-6 months to maintain the desired skin complexion.

However, it varies for every individuals and depends on skin condition. A combination of enery-based treatments may be recommended to obtain the best clinical results before moving onto maintenance treatment.

The effects of Nucleofill usually last for about 6-12 months, depending on how fast you age. Regular maintenance treatments for Nucleofill is recommeneded to maintain your desired goal.

Patient usually will start to experience improved skin hydration and radiance within weeks but it will take about 3-6 months to see the full effect of natural skin lifting and tightening, as it will some need time for biostimulating and biorestructing of collagen in the skin.

Nucleofill can be safely combined with other energy-based treatments for optimal results by accelerating the production of collagen in the skin. Energy-based treatments that is compatible with Nucleofill:

  • Pico Laser
  • Fractional CO2 Laser
  • HIFU
  • Ultherapy
  • Fotona4D


As Nucleofill consists of pure Polynucleotides, which is known for cellular regeneration (skin healing benefits), it also acts as a great “booster” for skin before other injection treatments to extend their aesthetic effects.

  • Pregnancy and lactation
  • Autoimmune diseases
  • Systemic diseases not decompensated
  • Cancer
  • Active herpes and other viral infections in the treatment site
  • Fungal and bacterial skin infections in the treatment site

V Medical Aesthetics and Laser Clinic has 16 clinic outlets across Singapore, located at:

Novena, Orchard, Somerset, Dhoby Ghaut, Tanjong Pagar, Bedok, Tampines, Pasir Ris, Woodlands, Serangoon, Boon Lay, Jurong East, Yishun and Toh Payoh.

Click here for clinic address.

By Appointment Only

Mon – Sat : 10.30am – 8.30pm, closed on Sun & Public Holidays.

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